hCG (human chorionic gonadotropin) – 5000 IU

buy hcg, In men, hCG preserves fertility and testicular function during testosterone therapy, restoring natural sperm production and preventing atrophy with excellent long-term safety.

In women, this proven hormone precisely triggers ovulation and supports egg maturation, dramatically improving success rates in IVF, IUI, and natural conception cycles.

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hCG (Human Chorionic Gonadotropin) is a potent glycoprotein hormone that mimics luteinizing hormone (LH), binding to LHCGR receptors to stimulate endogenous testosterone production, support testicular function, and maintain fertility.

Its unique beta subunit drives targeted activity, while downstream signaling via PKA and PKC pathways enhances steroidogenesis and cellular differentiation.

hCG also plays a critical role in modulating immune tolerance and vascularization, making it a cornerstone in recovery and hormone optimization protocols.

How women use hCG:

• hCG is given by injection (subcutaneous or intramuscular) as a “trigger shot” to induce final oocyte maturation and ovulation about 34–36 hours after dosing, typically using a single trigger dose prescribed by a fertility clinician.

• In assisted reproduction (IUI/IVF) it’s also used in specific lower or repeated doses for luteal support or protocol-dependent timing; dose and schedule depend on the protocol and clinician’s plan.

• Administration is clinic‑taught for home use (rotate injection sites, refrigerate product), and patients are screened/monitored because hCG can increase risk of ovarian hyperstimulation syndrome and thrombotic events, so follow‑up and exact dosing are important.

Mechanism of Action (Fertility)

• Mimics LH (Luteinizing Hormone): hCG binds to LH receptors in the ovaries and testes, triggering key reproductive processes.

• In Females: Stimulates the corpus luteum to produce progesterone, which stabilizes the endometrium and supports implantation and early pregnancy.

• In Males: Activates Leydig cells to produce testosterone, essential for spermatogenesis and testicular function.

Clinical Applications (Fertility)

• Ovulation Induction: hCG is used in assisted reproductive technologies (ART) to mimic the natural LH surge, triggering the release of a mature oocyte.

• Male Fertility Support: Often used in hypogonadotropic hypogonadism to restore testosterone levels and sperm production.

• Post-Cycle Recovery: hCG helps maintain fertility and testicular volume after suppression from exogenous hormones.

Biological Functions

• Reproductive roles:
  • Stimulates progesterone production from corpus luteum.
  • Maintains myometrial quiescence (prevents uterine contractions).
  • Promotes angiogenesis in uterine vasculature.
  • Facilitates trophoblast fusion and syncytiotrophoblast formation.
  • Signals endometrial receptivity for implantation.

• Immunomodulation:
  • Suppresses maternal immune response to fetal antigens.
  • Inhibits macrophage activity at the maternal-fetal interface.

Molecular Structure & Variants

• hCG is a glycoprotein hormone composed of two subunits:
  • Alpha subunit: Shared with LH, FSH, and TSH.
  • Beta subunit: Unique to hCG, confers biological specificity.

• There are a few distinct hCG variants, each with different origins and functions:
  • Standard hCG: Produced by syncytiotrophoblasts in the placenta.
  • Hyperglycosylated hCG: Made by cytotrophoblasts, promotes implantation and placental invasion.
  • Pituitary hCG: A sulfated form secreted during the menstrual cycle, mimics LH.

Mechanism of Action

• hCG binds to the LHCGR (LH/CG receptor), a G-protein-coupled receptor found in gonadal and uterine tissues.

• This activates intracellular signaling cascades:

• PKA (Protein Kinase A) and PKC (Protein Kinase C) pathways.

• Smad2 and TGFβR interactions, influencing gene transcription and cellular differentiation.