mazdutide vs tirzepatide, Mazdutide is a long-acting dual GLP-1 + glucagon receptor agonist peptide (oxyntomodulin analog with fatty-acid extension).
In published preclinical and in vitro work it shows: strong appetite suppression and insulin secretion (GLP-1 pathway) and increased energy expenditure and fat oxidation (glucagon pathway)
In previous trials, it was well tolerated with the lowest GI related dropout rates when compared to other popular GLP-1 peptides.
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Mazdutide (IBI362, OXM-3) is a research peptide that hits both GLP-1 and glucagon receptors at the same time.
The GLP-1 side does the usual: triggers insulin only when glucose is high, slams the brakes on excess glucagon, slows stomach emptying, and kills appetite through brain signaling.
The glucagon side does the opposite of what most people expect: instead of raising blood sugar, it ramps up energy burn, drives fat breakdown in the liver and fat tissue, and helps turn white fat into calorie-burning brown-like fat.
That extra energy-expenditure kick is why weight loss often lands in the 15–18 % range and lean mass is better preserved than with pure GLP-1 drugs.
It’s built as a long-acting version of the body’s own oxyntomodulin, with a fatty-acid chain added.
Already approved in China for type 2 diabetes and obesity; global phase 3 trials are still running.











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